| Title | [Tinidazole: a classical anaerobical drug with multiple potential uses nowadays.] | | Author(s) | Granizo J, Rodicio M, Manso F, Giménez M | | Source | Rev Esp Quimioter 2009 Jun; 22(2):106-14. | | Abstract | Tinidazole is a 5-nitroimidazole active in vitro against a wide variety of anaerobic bacteria and protozoa. Tinidazole is an effective treatment against anaerobic microorganisms based on its pharmacokinetic characteristics (Cmáx 51 microg/ml, t(1/2) 12.5 h) and its excellent in vitro activity. Its long half-life allows once a day regimens. Tinidazole is as effective as metronidazole in the treatment of infections caused by T. vaginalis, giardiasis and amebiasis and bacterial vaginosis, malaria, odontogenic infections, anaerobic bacterial infections (pelvic inflammatory disease, diabetic foot), surgical prophylaxis (abdominal and hysterectomy) and Helicobacter pylori eradication. Tinidazole was recently approved by the Food and Drug Administration (FDA) for the treatment of infections caused by Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia. Keywords: Tinidazol. Pharmacodynamia. Pharmacokinetics. Anaerobes. Helicobacter. Rev Esp Quimioter 2008;22(2):106-114. | | Language | spa | | Pub Type(s) | Editorial
English Abstract
| | PubMed ID | 19544102 |
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